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KMID : 0359920140330030139
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Korean Journal of Nephrology
2014 Volume.33 No. 3 p.139 ~ p.143
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Clinicopathological role of kidney injury molecule-1 in immunoglobulin A nephropathy
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Lee Yu-Ho
Kim Yang-Gyun
Lee Sang-Ho
Moon Ju-Young
Jeong Kyung-Hwan
Lee Tae-Won
Ihm Chun-Gyoo
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Abstract
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Background: Urinary kidney injury molecule-1 (KIM-1) is an early and sensitive biomarker of acute kidney injury, but it is unclear if it is a biomarker of chronic glomerulonephritis. We evaluated whether urinary KIM-1 levels in patients with immunoglobulin A (IgA) nephropathy can be a marker to re?ect clinicopathological severity and predict the prognosis.
Methods: We measured urinary KIM-1 levels in 40 patients (15 males; mean age 36.6712.9 years) with IgA nephropathy and 10 healthy people (5 males; mean age 37.379.6 years) as controls. The correlation of urinary KIM-1 levels with patients’ clinical parameters, histological grades, and follow-up data were analyzed using the modi?ed H. S. Lee grading system and tubulointerstitial change scores.
Results: Urinary KIM-1 levels were higher in patients with IgA nephropathy than healthy controls (P¼0.001). Univariate and multivariate regression analyses showed that urinary KIM-1 levels had a direct correlation with H. S. Lee grade and tubulointerstitial in?ammation (P¼0.004 and P¼0.011, respectively).
Conclusion: In patients with IgA nephropathy, urinary KIM-1 has a signi?cant correlation with histopathologic severity.
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KEYWORD
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IgA nephropathy, Kidney biomarkers, Kidney injury molecule-1 (KIM-1)
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